Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration.

Donghui Na, Zechen Zhang, Meng Meng, Meiyu Li, Junyan Gao, Jiming Kong, Guohui Zhang, Ying Guo

Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China.Department of Forensic Medicine, Hebei North University, Zhangjiakou, Hebei, China. · pubmed

Paper

Abstract

Aging is characterized by a gradual decline in physiological functions, with brain aging being a major risk factor for numerous neurodegenerative diseases. Given the brain's high energy demands, maintaining an adequate ATP supply is crucial for its proper function. However, with advancing age, mitochondria dysfunction and a deteriorating energy metabolism lead to reduced overall energy production and impaired mitochondrial quality control (MQC). As a result, promoting healthy aging has become a key focus in contemporary research. This review examines the relationship between energy metabolism and brain aging, highlighting the connection between MQC and energy metabolism, and proposes strategies to delay brain aging by targeting energy metabolism.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that targeting energy metabolism and mitochondrial quality control can delay brain aging. This research is relevant as it addresses the underlying mechanisms of aging and proposes strategies to mitigate neuronal degeneration, which aligns with the goals of longevity research.

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