Impact of aging on spermatogenic function and reproductive outcomes in repro57 heterozygous male mice: A model for age-related infertility.

Yuto Aoki, Misaki Wakamatsu, Nanami Sono, Wei Xiao, Emi Ishii, Takeshi Nagai, Yasushi Nagai, Yasuhiro Fujiwara, Tetsuo Kunieda, Junko Otsuki

Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University, 1 - 1- 1 Tsushimanaka, Kita, Okayama, 700 - 8530, Japan.Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University, 1 - 1- 1 Tsushimanaka, Kita, Okayama, 700 - 8530, Japan. · pubmed

Paper

Abstract

This study aims to investigate the histological changes, sperm parameters, and their impact on embryo development rates and offspring numbers in advanced-age male repro57 heterozygous mice, corresponding to approximately 40 years of age in humans.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that aging negatively affects spermatogenic function and reproductive outcomes in male repro57 heterozygous mice. This research is relevant as it explores the biological mechanisms of aging and their impact on reproductive health, which can contribute to understanding age-related infertility.

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