Senolytic treatment alleviates cochlear senescence and delays age-related hearing loss in C57BL/6J mice.

Yi Chen, Hongming Huang, Yuelian Luo, Haoyang Wu, Wenting Deng, Xin Min, Huilin Lao, Hao Xiong

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou 510120, China. · pubmed

Paper

Abstract

Age-related hearing loss (ARHL) is a prevalent sensory deficit that significantly affects quality of life in older individuals. Cellular senescence contributes to various age-related degenerative disorders. However, its effect on ARHL remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Senolytic treatment can alleviate cochlear senescence and delay age-related hearing loss in mice. This research addresses the underlying mechanisms of aging by targeting cellular senescence, which is a contributing factor to age-related diseases, thus aligning with longevity research.

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