Telomere Length and Cognitive Function Among Middle-Aged and Older Participants From Communities Underrepresented in Aging Research: A Preliminary Study.

Lauren W Y McLester-Davis, Derek Norton, Ligia A Papale, Taryn T James, Hector Salazar, Sanjay Asthana, Sterling C Johnson, Diane C Gooding, Trevor R Roy, Reid S Alisch, Kirk J Hogan, Stacy S Drury, Carey E Gleason, Megan Zuelsdorff

Native American Center for Health Professions, University of Wisconsin, Madison, WI, USA. · pubmed

Paper

Abstract

ObjectiveAccelerated biological aging is a plausible and modifiable determinant of dementia burden facing minoritized communities but is not well-studied in these historically underrepresented populations. Our objective was to preliminarily characterize relationships between telomere length and cognitive health among American Indian/Alaska Native (AI/AN) and Black/African American (B/AA) middle-aged and older adults.MethodsThis study included data on telomere length and neuropsychological test performance from 187 participants, enrolled in one of two community-based cognitive aging cohorts and who identified their primary race as AI/AN or B/AA.ResultsNested multivariable regression models revealed preliminary evidence for associations between telomere length and cognitive performance, and these associations were partially independent of chronological age.DiscussionSmall sample size limited estimate precision; however, findings suggest future work on telomere length and cognitive health in underrepresented populations at high risk for dementia is feasible and valuable as a foundation for social and behavioral intervention research.

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Research summary

The paper suggests that there are associations between telomere length and cognitive performance in underrepresented populations. This study is relevant as it explores biological aging markers (telomere length) in relation to cognitive health, addressing potential root causes of aging-related cognitive decline in historically marginalized communities.

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