Qi-Gu capsule alleviates osteoporosis by inhibiting mesenchymal stem cell senescence via the HIF-1α/AMPK axis.

Xuan Wan, Pengchao Xu, Xing Zhou, Jiangyuan Liu, Yiwen Yang, Chaoyi Liang, Jinglei Wang, Weixiang Wang, Fengjiao Xu, Xiaoming Wan, Jian Kang, Peijian Tong, Hanting Xia

Department of Orthopedics, Affiliated hospital of Jiangxi University of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi province 330004, China; University Medicine Rostock, University of Rostock, Parkstr. 6, Rostock 18057, Germany. · pubmed

Paper

Abstract

Osteoporosis (OP) represents a systemic disease causing reduced bone mass and fragility fractures. Qigu Capsule (QGC), a traditional Chinese medicine, shows potential in alleviating human OP, but its precise mechanisms remain unclear, limiting clinical application.

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Research summary

Qi-Gu capsule alleviates osteoporosis by inhibiting mesenchymal stem cell senescence via the HIF-1α/AMPK axis. The paper addresses a mechanism related to cellular senescence, which is a key factor in aging and age-related diseases.

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