Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals.

Xiaorong Lin, Yanhua Du, Shuo Kan, Junjie Chen, Yunxue Yin, Linlin Li, Jingwen Chen, Wenrong Jiang, Wenqiang Cao, Chulwoo Kim, Liang Chen, Shiwen Wang, Jorg J Goronzy, Jun Jin

Multiscale Research Institute for Complex Systems, Fudan University, Shanghai, China. · pubmed

Paper

Abstract

T cell aging contributes to the lower vaccine efficacy in older adults, yet the molecular mechanism remains elusive. Here, we show the density of initially responding naïve CD4

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Research summary

Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals. This research addresses a molecular mechanism related to T cell aging, which is a fundamental aspect of the aging process and its impact on immune function, thus contributing to our understanding of aging and potential interventions.

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