Nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton regulate spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes.

Hyo-Jin Park, Seul-Gi Yang, Ji-Hyun Shin, Seung-Bin Yoon, Ji-Su Kim, Deog-Bon Koo

Department of Biotechnology, College of Engineering, Daegu University, 201 Daegudae-Ro, Jillyang, Gyeongsan, Gyeongbuk, 38453, Republic of Korea. · pubmed

Paper

Abstract

Post-ovulatory aging (POA) is associated with reduced fertilization rates and poor embryo quality both in vivo and in vitro. However, the relationship between nicotinamide adenine dinucleotide (NAD

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Research summary

The paper claims that nicotinamide mononucleotide biosynthesis and the F-actin cytoskeleton play a role in regulating spindle assembly and oocyte maturation quality in post-ovulatory aged porcine oocytes. This research addresses mechanisms related to cellular aging and oocyte quality, which are relevant to understanding the aging process and potential interventions.

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