Recent research advances of c-fos in regulating cell senescence.

Yuxin Jing, Wei Zheng, Zhou Zhou, Haiyang Yao, Wenchuan Zhang, Yilun Wu, Zimo Guo, Chenxuan Huang, Xianli Wang

Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: [email protected] Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

c-fos is an immediate early gene (IEG) that forms a heterodimeric activator protein-1 (AP-1) complex with c-Jun. Following stimulation by a variety of factors, it changes the expression of genes and participates in cellular growth, proliferation, differentiation, and apoptosis. Previous studies have reported that c-fos is linked to cellular senescence and is involved in aging-related signaling pathways or damage repair processes. However, there are limited studies related to this topic. This review summarizes the findings of the connection between c-fos and cellular senescence, including the regulatory role of c-fos in the senescence of stem cells and various kinds of somatic cells. In addition, we discussed the involvement of c-fos in the cellular senescence process and related signaling pathways, as well as the importance of regulating DNA damage repair. The current studies have demonstrated that c-fos has important roles in inhibiting stem cell senescence. They can pave the way for a more thorough examination of the aging process and the regeneration of stem cells and provide new therapeutic strategies for aging-related diseases.

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Research summary

c-fos plays a regulatory role in cellular senescence and may provide new therapeutic strategies for aging-related diseases. The paper discusses mechanisms that could potentially address the root causes of aging through the regulation of cellular senescence.

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