Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms.

Yun-Fei Zhu, Xing-Yue Zhou, Cai Lan, Yong-Ping Wen, Hai-Jun Fu, Zhi-Chao Li, Ya-Ping Li, Shi-Ying Li, Fei-Hong Huang, Long Wang, Lu Yu, Da-Lian Qin, An-Guo Wu, Jian-Ming Wu, Xiao-Gang Zhou

Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China. · pubmed

Paper

Abstract

Aging leads to progressive decline in the functions of cells, tissues, and organs, severely affecting muscle performance and overall health, highlighting the urgent need for effective therapeutic agents. This study investigated the antiaging properties of tricin, a flavonoid abundant in grains, using biological models, including human fibroblasts,

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Tricin activates AMPK-mediated autophagy to delay aging and enhance muscle function. This study addresses the mechanisms of aging and proposes a potential therapeutic agent that targets fundamental processes related to aging.

Author of this paper? Send a correction.