Beyond the ends: Potential implications of Telomeric Repeat-Containing RNA (TERRA) for CNS Diseases.

Hadjer Namous, Raghu Vemuganti

Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA. · pubmed

Paper

Abstract

Telomeric Repeat-Containing RNA (TERRA) is a class of noncoding RNAs (ncRNAs) emanating from telomeres and control telomere dynamics. Recent studies showed that TERRAs influence chromatin structure and gene expression. TERRAs can also play a crucial role in controlling inflammation, oxidative stress, DNA damage, and cellular senescence. This review article discussed the significance of TERRAs in modulating these processes, particularly in CNS. While our understanding of TERRAs largely stems from cancer research, their involvement in these physiologic and pathologic pathways highlights their potential as therapeutic targets for CNS disorders as well.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

TERRAs play a crucial role in controlling inflammation, oxidative stress, DNA damage, and cellular senescence, which are all processes associated with aging. The paper is relevant as it discusses potential therapeutic targets that could address underlying mechanisms of aging and age-related diseases.

Author of this paper? Send a correction.