The mechanism underlying of Zuoguiyin on liver and kidney in D-gal-induced subacute aging female rats: A perspective on SIRT1-PPARγ pathway regulation of oxidative stress, inflammation and apoptosis.

Jingru Xie, Baobao Li, Cunbao He, Shubin Yang, Shaojie Yang, Peiyang Sun, Guoqi Zhu, Jingji Wang

The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230061, China. Electronic address: [email protected] Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230061, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aging is a complex biological metabolic process. Traditional Chinese Medicine (TCM) theory posits that deficiencies in the liver and kidneys in women is closely associated with aging. Zuoguiyin (ZGY), originating from the Jing Yue Quan Shu (A.D. 1624), is renowned for its efficacy in nourishing Yin and tonifying the kidneys. Pharmacological studies have confirmed that ZGY could enhance liver and kidney functions in aging females, but its molecular mechanisms remain unclear.

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Research summary

The paper investigates the molecular mechanisms of Zuoguiyin in enhancing liver and kidney functions in aging female rats through the SIRT1-PPARγ pathway. This research is relevant as it explores potential interventions targeting the biological processes associated with aging rather than merely addressing age-related symptoms.

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