The mitochondrial unfolded protein response: acting near and far.

Nikolaos Charmpilas, Qiaochu Li, Thorsten Hoppe

Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, D-50931 Cologne, Germany.Institute for Genetics, University of Cologne, Joseph-Stelzmann-Str. 26, D-50931 Cologne, Germany. · pubmed

Paper

Abstract

Mitochondria are central hubs of cellular metabolism and their dysfunction has been implicated in a variety of human pathologies and the onset of aging. To ensure proper mitochondrial function under misfolding stress, a retrograde mitochondrial signaling pathway known as UPR

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the mitochondrial unfolded protein response (UPR) as a mechanism to maintain mitochondrial function under stress. This research is relevant as it addresses mitochondrial dysfunction, which is a key factor in aging and age-related diseases, potentially offering insights into the root causes of aging.

Author of this paper? Send a correction.