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RESEARCH PAPER / 2025-04-16

Mediation role of telomere length in the relationship between physical activity and PhenoAge: A population-based study.

Yanwei You, Dizhi Wang, Hao Ding, Weizhao Wang, Qiyu Liu, Danyi Zhang, Yuquan Chen, Xindong Ma

Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China. · pubmed

Abstract

The relationship between physical activity (PA), telomere length, and phenotypic age (PhenoAge) represents a pivotal area of investigation in aging research.

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Research summary

Telomere length mediates the relationship between physical activity and phenotypic age. This study explores fundamental biological mechanisms associated with aging, linking physical activity to telomere dynamics and their implications for biological aging, which is central to longevity research.

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