High glucose induces senescence in synovial mesenchymal stem cells through mitochondrial dysfunction.

Shuyi Tan, Wangxi Wu, Yifan Chen, Hai Gao

Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China. · pubmed

Paper

Abstract

To investigate the impact of high glucose on the senescence of synovial mesenchymal stem cells (SMSCs) and to elucidate the role of mitochondrial dysfunction in this process.

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Research summary

High glucose induces senescence in synovial mesenchymal stem cells through mitochondrial dysfunction. The study addresses the cellular mechanisms of aging by exploring how high glucose levels contribute to stem cell senescence, which is relevant to understanding the aging process and potential interventions.

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