Comparative study of ginsenoside Rg2, 20(S)-protopanaxatriol, and AFG from ginseng on aging-related kidney injury in SAMP8 mice.

Ivan Steve Nguepi Tsopmejio, Jing-Tian Zhang, Zi Wang, Zhao-Feng Tian, Hong-Yan Zhu, Jing Zhang, Shen Ren, Shuang Liu, Jin-Hui Liu, Jun-Nan Hu, Wei Li

College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; College of Life Sciences, Engineering Research Center of the Chinese Ministry of Education for Biorector and Pharmaceutical Development, Jilin Agricultural University, Changchun 130118, China.College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Jilin Agricultural University, Changchun 130118, China; College of Life Sciences, Engineering Research Center of the Chinese Ministry of Education for Biorector and Pharmaceutical Development, Jilin Agricultural University, Changchun 130118, China. · pubmed

Paper

Abstract

Aging contributes to various pathologies, including kidney injury, but the therapeutic potential of natural drugs in these contexts remains inadequately assessed. The roots of Panax ginseng C.A. Meyer, a widely used traditional Chinese medicine, are reputed for their anti-aging properties and life-prolonging effects, yet their specific medicinal components and mechanisms of action require further exploration.

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Research summary

The paper investigates the effects of specific ginsenosides on aging-related kidney injury in a mouse model. This research is relevant as it explores potential therapeutic agents that may address mechanisms underlying aging and age-related diseases.

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