Extracellular matrix modulating effects of amnion-derived mesenchymal stem cells on aging skin wounds in α-Klotho knockout mice.

Yuki Sasaki, Shunsuke Ohnishi, Hiroko Takahashi, Kosuke Ishikawa, Takahiro Miura, Emi Funayama, Naoto Okubo, Yuhei Yamamoto, Taku Maeda

Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan. · pubmed

Paper

Abstract

Wounds in the elderly are frequently recalcitrant and chronic as a result of the effects of skin aging and associated complications. The objective of this study is to utilize an α-Klotho knockout (KO) mice wound model to assess the capacity of amnion-derived mesenchymal stem cells (AMSCs) to facilitate wound healing in aging skin.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that amnion-derived mesenchymal stem cells can enhance wound healing in aging skin. This research addresses a specific aspect of aging-related tissue regeneration, which is relevant to longevity and age-related diseases.

Author of this paper? Send a correction.