Identification of Nitric Oxide Donating Dasatinib Derivatives with Intraocular Pressure Lowering and Senolytic Activities.

Zhongshu Pan, Jiaming Zhang, Haoyu Zuo, Cunrui Li, Huiying Song, Haohan Yang, Keling Wu, Minglei Zhao, Zirong Zhang, Yuhua Lai, Jingyi Luo, Jianbing Wu, Ling Zhao, Zhangjian Huang

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, P. R. China. · pubmed

Paper

Abstract

Based on two major risk factors of glaucoma, elevated intraocular pressure (IOP) and senescence, two new series of nitric oxide (NO) donating dasatinib derivatives

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to identify new nitric oxide donating dasatinib derivatives that lower intraocular pressure and exhibit senolytic activities. The focus on senolytic activities suggests an attempt to address cellular senescence, which is a root cause of aging and age-related diseases.

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