Relationship between physical activity and DNA methylation-predicted epigenetic clocks.

Yanwei You, Yuquan Chen, Hao Ding, Qiyu Liu, Rui Wang, Kailin Xu, Qingyuan Wang, Danijela Gasevic, Xindong Ma

Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China. · pubmed

Paper

Abstract

This study investigates the relationship between physical activity (PA) levels and DNA methylation (DNAm)-predicted epigenetic clocks in a U.S. population sample (n = 948, mean age 62, 49% female). Eight epigenetic clocks were analyzed, revealing that higher PA levels were significantly associated with younger biological ages across all indicators, with the strongest effects observed for SkinBloodAge and LinAge. Multivariable linear regression models, adjusted for sociodemographic and lifestyle factors, highlighted the potential of PA to reduce biological ageing. Subgroup analyses indicated that these associations were more pronounced among non-Hispanic whites, individuals with a BMI of 25-30, and former smokers, suggesting that the impact of PA varies across different groups. These findings emphasize the role of PA in slowing biological ageing and reducing age-related health risks. Promoting regular PA, especially among older adults and those with higher BMI, could improve well-being and lifespan, highlighting PA as a modifiable factor in healthy ageing and age-related disease prevention.

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Research summary

Higher physical activity levels are associated with younger biological ages as predicted by DNA methylation clocks. This study addresses the modifiable factor of physical activity in relation to biological aging, which is directly relevant to longevity research and the prevention of age-related diseases.

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