6'-O-caffeoylarbutin attenuates D-galactose-induced brain and liver damage in aging mice via regulating SIRT1/NF-κB pathway.

Yongpeng Wang, Yongchao Wang, Tianrui Zhao, Wenbing Zhou, Afsar Khan, Jianxin Cao, Yaping Liu, Zhengxuan Wang, Guiguang Cheng

Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, PR China.Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, 650500, PR China. · pubmed

Paper

Abstract

Aging-related liver and brain damage caused by oxidative stress and inflammation significantly impacts health and quality of life. Natural bioactive compounds, such as 6'-O-caffeoylarbutin (CA), which is primarily distributed in Vaccinium species, have been studied for their antioxidant and anti-inflammatory properties. This study aims to investigate the protective effect on liver and brain damage induced by D-galactose (D-gal) in mice and to explore its potential molecular mechanisms.

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Research summary

The paper claims that 6'-O-caffeoylarbutin protects against D-galactose-induced brain and liver damage in aging mice through the SIRT1/NF-κB pathway. This research addresses oxidative stress and inflammation, which are key factors in the aging process, thus contributing to the understanding of potential interventions in age-related damage.

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