Central adiposity and α-klotho: inflammatory mechanisms underlying aging biomarkers related to body roundness index.

Rui Du, Xiaoyan Tang, Lei Guan, Yuchen Lai, Huijuan Xiang, Wei Huang

Department of Ultrasound, General Hospital of Central Theater Command, No. 627, Wuluo Road, Hubei, 430070, Wuhan, China.Department of Ultrasound, General Hospital of Central Theater Command, No. 627, Wuluo Road, Hubei, 430070, Wuhan, China. · pubmed

Paper

Abstract

Obesity is a global health issue which has been widely accepted as an aging related pathogenesis. α-Klotho is a protein involved in aging process, mineral metabolism, insulin sensitivity, and the pathogenesis of various age-related diseases. Adiposity correlates with lower soluble α-Klotho, but the role of fat distribution and inflammation remains unclear. The body roundness index (BRI) refines central adiposity assessment beyond BMI. Herein, We aimed to investigate the relationship of BRI, inflammation and serum level of soluble α-Klotho.

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Research summary

The paper investigates the relationship between body roundness index, inflammation, and soluble α-Klotho levels. This research is relevant as it explores potential mechanisms linking central adiposity and inflammation to aging biomarkers, contributing to the understanding of aging processes.

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