The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1.

Wei Luo, Jiming Zhou, Feng Liang, Xianghui Chou, Zhengliang Peng, Weihua Tan, Ziying Yu, Huan Wan

Department of Cardiology, The First Affiliated Hospital of University of South China, No. 69, Chuanshan Road, Shigu District, Hengyang, 421001, Hunan, China. · pubmed

Paper

Abstract

Cell senescence-associated endothelia dysfunction is a vital point in the pathological progression of atherosclerosis (AS). G-protein coupled receptor 4 (GPR4) is a proton-sensing receptor involved in developing endothelial dysfunction.

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Research summary

The paper claims that the GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1. The research addresses cellular senescence, which is a key mechanism in aging and age-related diseases, suggesting potential pathways for longevity interventions.

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