Spermidine toxicity in Saccharomyces cerevisiae due to mitochondrial complex III deficiency.

Wei-Hsuan Su, Jessica J Smith, Evien Cheng, Megan S Nishitani, Catherine Y Choi, Kelsey R Lee, Alexia Pardos Salzano, Samuel E Schriner

School of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA.School of Pharmacy and Pharmaceutical Sciences, University of California, Irvine, CA, USA. · pubmed

Paper

Abstract

Spermidine is a naturally occurring polyamine present in all cells and is necessary for viability in eukaryotic cells. The cellular levels of spermidine decline as an organism ages, and its supplementation has been found to extend lifespan in yeast, worms, flies, mice, and human cultured cells. The lifespan extending effect of spermidine is thought to be due to its ability to induce autophagy, a turnover of cellular components. Mitochondrial dysfunction is believed to be a major driver of the aging process. We asked whether spermidine could rescue mitochondrial dysfunction using the yeast Saccharomyces cerevisiae lacking mtDNA (ρ

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Research summary

The paper investigates the toxicity of spermidine in yeast with mitochondrial complex III deficiency. This research is relevant as it explores the role of spermidine in mitochondrial dysfunction, which is a significant factor in the aging process and lifespan extension.

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