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RESEARCH PAPER / 2025-04-10

A cohort study on the correlation between serum Klotho levels and all-cause mortality in American diabetic populations.

Kangxiang Wu, Jiaqi Chen, Yiying Lin, Jie Wang

Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. · pubmed

Abstract

The global prevalence of diabetes is on an upward trajectory. The management of complications related to the condition has seen limited progress in recent years. Klotho, characterized as an anti-aging protein that mitigates oxidative stress and inflammation, has previously been correlated with all-cause mortality in the broader United States population. The objective of this research was to investigate the persistence of this relationship among diabetic patients.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the correlation between serum Klotho levels and all-cause mortality in diabetic patients. This research is relevant as it explores a potential biomarker associated with aging and longevity, specifically in the context of a population affected by a chronic condition that is closely linked to age-related health issues.

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