Association between aging phenotypes and chronic kidney disease: evidence from the NHANES and Mendelian randomization.

Yukai Zhang, Chenwei Zhang, Peiyun He, Xinling Tian, Yuzhe Kong, Yun Zhou

The First Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China.The First Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China. · pubmed

Paper

Abstract

Biological aging was found to be associated with the higher prevalence of several diseases, but it is unclear in the prevalence of chronic kidney disease (CKD). This study investigated the effect of aging phenotypes, characterized by PhenoAge (PA), Klemera-Doubal Method (KDM), allostatic load (AL), homeostatic dysregulation (HD), and telomere length (TL) on CKD from the perspective of both clinical relevance and genetic susceptibility.

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Research summary

The study claims that specific aging phenotypes are associated with the prevalence of chronic kidney disease. This paper is relevant as it explores the relationship between biological aging and a chronic condition, potentially shedding light on underlying mechanisms of aging-related diseases.

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