Senescence-related cytokine levels are associated with HIV-1 serostatus and persistence.

Yijia Li, Zoamy N Soto-Ramirez, Jennifer Roscher, Tom Medvec, Mounia Alaoui-El-Azher, Paolo Piazza, Yue Chen, Nicolas Sluis-Cremer, Charles R Rinaldo, Bernard J C Macatangay

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA.Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA. · pubmed

Paper

Abstract

HIV-1 infection is associated with accelerated aging. The senescence-associated secretory phenotype (SASP) includes biological and cytokine profiles that induce cellular senescence and inflammaging. In this study, we leveraged the Multicenter AIDS Cohort Study (MACS) to evaluate the role of SASP in aging, HIV-1 reservoir, and inflammation in people with HIV-1 (PWH) on long-term suppressive antiretroviral therapy (ART).

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Research summary

The paper claims that senescence-related cytokine levels are associated with HIV-1 serostatus and persistence in individuals on long-term ART. This research is relevant as it explores the biological mechanisms of aging and inflammation in the context of HIV-1, contributing to our understanding of accelerated aging processes in people living with HIV.

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