Chromatin and epigenetics in aging biology.

Eric Lieberman Greer, Siu Sylvia Lee, Veena Prahlad

Department of Pediatrics, Washington University School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.Department of Pediatrics, Washington University School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA. · pubmed

Paper

Abstract

This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are deciphered by the cell to impact aging. In this chapter, we will review how chromatin modifications change with age, examine how chromatin-modifying enzymes have been shown to regulate aging and healthspan, discuss how some of these epigenetic changes are triggered and how they can regulate the lifespan of the individual and its naïve descendants, and speculate on future directions for the field.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Chromatin modifications influence aging and healthspan through their regulation by chromatin-modifying enzymes. The paper is relevant as it addresses the molecular mechanisms underlying aging, focusing on epigenetic changes that could potentially inform strategies for lifespan extension and healthspan improvement.

Author of this paper? Send a correction.