Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia.

Adam Nyul-Toth, Santny Shanmugarama, Roland Patai, Rafal Gulej, Janet Faakye, Dorina Nagy, Mark Nagykaldi, Tamas Kiss, Tamas Csipo, Madison Milan, Shoba Ekambaram, Sharon Negri, Raghavendra Y Nagaraja, Anna Csiszar, Jacob L Brown, Holly Van Remmen, Anna Ungvari, Andriy Yabluchanskiy, Stefano Tarantini, Zoltan Ungvari

Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. · pubmed

Paper

Abstract

Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in maintaining skeletal muscle health, acting both directly on muscle fibers to promote growth and indirectly by supporting the vascular network that sustains muscle perfusion. However, the microvascular consequences of IGF- 1 deficiency in aging muscle remain poorly understood. To elucidate how impaired IGF- 1 input affects skeletal muscle vasculature, we examined the effects of endothelial-specific IGF- 1 receptor (IGF- 1R) deficiency using a mouse model of endothelial IGF- 1R knockdown (VE-Cadherin-CreER

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Research summary

Endothelial IGF-1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance. This study addresses the role of IGF-1 in maintaining muscle health and its implications for age-related sarcopenia, which is directly related to the aging process and potential interventions for age-related decline.

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