High-Intensity Interval Training Combined with Glycine Supplementation Drives Ferroptosis Resistance to Counteract Skeletal Muscle Atrophy in Aging Mice.

Pin-Shi Ni, Meng-Meng Jia, Jia-Han He, Zhi Yu, Fang-Hui Li

School of Sport Sciences, Nanjing Normal University, Nanjing, CHINA. · pubmed

Abstract

This study aimed to investigate the molecular mechanisms underlying the improvement of aged skeletal muscle atrophy by high-intensity interval training (HIIT) combined with glycine supplementation.

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Research summary

The paper claims that high-intensity interval training combined with glycine supplementation can enhance resistance to ferroptosis, thereby mitigating skeletal muscle atrophy in aging mice. This research addresses a mechanism related to muscle atrophy, which is a significant aspect of aging and its associated decline in physical function, making it relevant to longevity studies.

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