Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in

Zheng Cao, Cui Zhang, Lijun Liu, Hehua Lei, Huabao Zhang, Yanmeng He, Xinzhi Li, Qingwei Xiang, Yu-Feng Wang, Limin Zhang, Gang Chen

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences (CAS), Wuhan, China. · pubmed

Paper

Abstract

Disruption of aryl hydrocarbon receptor (AhR) signaling and aberrant tryptophan metabolism have been shown to be highly associated with aging and age-related disorders. However, the underlying molecular mechanisms by which the AhR-mediated signaling pathway contributes to the aging process remain largely unknown. In this study, we find that aged

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Research summary

Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway. The study investigates the molecular mechanisms of the AhR signaling pathway in relation to aging, which aligns with efforts to understand and potentially mitigate the root causes of aging.

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