Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation.

Tian-Jin Huang, Shu Shang, Qin Wan, Qiang Li, Yang-Jingsi Li, Jin-Na Zheng, Fa-Xiu Chen

Department of Geriatrics, Jiangxi Provincial People's Hospital, No. 92 Aiguo Rd, Donghu District, Nanchang, Jiangxi, 330006, China.Department of Geriatrics, Jiangxi Provincial People's Hospital, No. 92 Aiguo Rd, Donghu District, Nanchang, Jiangxi, 330006, China. · pubmed

Paper

Abstract

Sarcopenia, the age-related decline in muscle mass and function, poses a major health risk to the elderly population. Although dietary advanced glycation end-products (AGEs) have been implicated in worsening sarcopenia, the precise molecular mechanisms remain unclear.

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Research summary

Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation. The paper addresses a mechanism related to sarcopenia, which is a significant age-related condition affecting muscle mass and function, thus contributing to the understanding of aging processes.

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