Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state.

Ji-Won Shin, Dong-Hyun Jang, So Young Kim, Je-Jung Lee, Tae-Hwan Gil, Eunha Shim, Ji Yeon Kim, Hyeon Soo Kim, Michael J Conboy, Irina M Conboy, Christopher D Wiley, Jeon-Soo Shin, Ok Hee Jeon

Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea. · pubmed

Paper

Abstract

Cellular senescence spreads systemically through blood circulation, but its mechanisms remain unclear. High mobility group box 1 (HMGB1), a multifunctional senescence-associated secretory phenotype (SASP) factor, exists in various redox states. Here, we investigate the role of redox-sensitive HMGB1 (ReHMGB1) in driving paracrine and systemic senescence.

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Research summary

The paper claims that the propagation of senescent phenotypes is influenced by the redox state of HMGB1. This research is relevant as it explores mechanisms underlying cellular senescence, which is a key factor in aging and age-related diseases, potentially offering insights into the root causes of these processes.

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