Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination.

Paul Kunath, Dominik Pflumm, Bettina Moehrle, Vadim Sakk, Alina Seidel, Jan Münch, Hartmut Geiger, Reinhold Schirmbeck

Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany. · pubmed

Paper

Abstract

Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Old hematopoietic stem cells can effectively reconstitute a youthful B cell system that responds well to vaccination. This research addresses the aging process by exploring the potential of old stem cells to maintain functionality, which is relevant to understanding and potentially mitigating age-related decline in immune response.

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