Collagen type V alpha 3 chain is involved in human skin basement membrane physiology and MMP-9 regulation.
Abstract
Collagens are widely studied proteins given their implications in the skin extracellular matrix and pathological conditions such as fibrosis. Type V collagen is a member of the fibrillar collagens, and three different polypeptide chains, α1, α2 and α3 form isoforms through associations. The third chain, α3, of type V collagen was initially identified in the placenta, but after decades, it remains poorly characterized. The aim of this study is to investigate the expression and localization of the α3 chain of type V collagen in the skin and its evolution during skin aging. The identification of α3(V) collagen as a target of retinoic acid and its interaction with matrix metalloproteinase-9 (MMP-9) was investigated.
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Research summary
The study investigates the role of collagen type V alpha 3 chain in skin aging and its regulation of MMP-9. This research is relevant as it explores the molecular mechanisms involved in skin aging, which is a fundamental aspect of the aging process.
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