Urolithin as a Metabolite of Ellagitannins and Ellagic Acid from Fruits and Nuts Produced by the Gut Microbiota: Its Role on Non-Communicable Diseases.

Marcia Ribeiro, Livia Alvarenga, Ludmila F M F Cardozo, Beatriz G Baptista, Danielle Nascimento, Marta Esgalhado, Denise Mafra

Graduate Program in Biological Sciences - Physiology, IBCCF, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro (RJ), Brazil. [email protected] Program in Biological Sciences - Physiology, IBCCF, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro (RJ), Brazil. [email protected]. · pubmed

Paper

Abstract

This narrative review investigates how urolithins produced by the gut microbiota can regulate transcription factors (such as NRF2, NF-kB, and PPAR-γ) associated with senescence, inflammation, and imbalanced redox status. It also discusses the potential benefits of urolithins for patients with chronic diseases, including cardiovascular disease, cancer, diabetes, obesity, and chronic kidney disease.

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Research summary

Urolithins produced by gut microbiota may regulate key transcription factors linked to aging and chronic diseases. The paper discusses mechanisms that could influence the root causes of aging-related processes, making it relevant to longevity research.

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