Genetically determined α-Klotho levels and causal association with aging-related lung diseases.

Chen Jin, Ruiying Jin, Dingyu Liu, Yuwen Li

Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University and School of Public Health, Hangzhou Normal University, Hangzhou, 311121, China.Key Laboratory of Aging and Cancer Biology of Zhejiang Province, School of Basic Medical Sciences, Hangzhou Normal University and School of Public Health, Hangzhou Normal University, Hangzhou, 311121, China. · pubmed

Paper

Abstract

Abnormal α-Klotho (KL) levels play an essential role in the pathogenesis of aging-related lung diseases. However, the correlation between circulating KL levels and aging-related lung diseases has not been determined. This study aimed to determine whether circulating KL levels causally affect aging-related lung diseases using Mendelian randomization (MR).

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Research summary

The study claims that genetically determined circulating α-Klotho levels causally affect aging-related lung diseases. This research is relevant as it investigates a potential biological mechanism linked to aging and its impact on age-related diseases, rather than merely addressing symptoms.

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