Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation.

Sofie Lautrup, Shi-Qi Zhang, Shinichiro Funayama, Lisa Lirussi, Tina Visnovska, Hoi-Hung Cheung, Marc Niere, Yuyao Tian, Hilde Loge Nilsen, Geir Selbæk, Janna Saarela, Yoshiro Maezawa, Koutaro Yokote, Per Nilsson, Wai-Yee Chan, Hisaya Kato, Mathias Ziegler, Vilhelm A Bohr, Evandro F Fang

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway.Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway. · pubmed

Paper

Abstract

Werner syndrome (WS), caused by mutations in the RecQ helicase WERNER (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Decreased mitochondrial NAD+ levels in WRN deficient cells are linked to dysfunctional proliferation. This research addresses a potential root cause of aging by exploring the role of mitochondrial function and NAD+ in cellular proliferation, which is relevant to understanding aging mechanisms.

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