Neuroprotective role of Hippo signaling by microtubule stability control in
Abstract
The evolutionarily conserved Hippo (Hpo) pathway has been shown to impact early development and tumorigenesis by governing cell proliferation and apoptosis. However, its post-developmental roles are relatively unexplored. Here, we demonstrate its roles in post-mitotic cells by showing that defective Hpo signaling accelerates age-associated structural and functional decline of neurons in
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Research summary
Defective Hippo signaling accelerates age-associated structural and functional decline of neurons. The paper explores the role of Hippo signaling in post-mitotic cells, which is directly related to understanding mechanisms of aging and potential interventions to mitigate age-related neuronal decline.
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