Exercise training restores longevity-associated tryptophan metabolite 3-hydroxyanthranilic acid levels in middle-aged adults.

Niklas Joisten, Marcel Reuter, Friederike Rosenberger, Andreas Venhorst, Marie Kupjetz, David Walzik, Alexander Schenk, Adrian McCann, Per Magne Ueland, Tim Meyer, Philipp Zimmer

Division of Exercise and Movement Science, Institute for Sport Science, University of Göttingen, Göttingen, Germany. · pubmed

Paper

Abstract

Recent pre-clinical evidence suggests that the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) and the related enzyme activity along the kynurenine metabolic pathway (KP) are associated with lifespan extension. We aimed to translate these findings into humans and expose exercise training as a potential non-pharmacological intervention to modulate this metabolic hub.

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Research summary

Exercise training can restore levels of the longevity-associated tryptophan metabolite 3-hydroxyanthranilic acid in middle-aged adults. This research is relevant as it explores a non-pharmacological intervention that may influence metabolic pathways associated with lifespan extension.

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