ALKBH5 Regulates Macrophage Senescence and Accelerates Atherosclerosis by Promoting CCL5 m

Rifeng Gao, Jiaran Shi, Yang Lyu, Bichen Ren, Wei Wei, Jiahui Cheng, Juntao Chen, Yan Zhou, Jianxin Chen, Xiaolei Sun, Jun Jiang, Bo Li, Kun Yang

Department of Cardiac Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China (R.G., Jianxin Chen, J.J., K.Y.).Department of Cardiac Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China (R.G., Jianxin Chen, J.J., K.Y.). · pubmed

Paper

Abstract

Senescent foamy macrophages are key drivers of atherosclerosis and plaque instability. N

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

ALKBH5 regulates macrophage senescence and promotes CCL5, contributing to atherosclerosis progression. The study addresses the role of cellular senescence in macrophages, which is a key aspect of aging and its associated diseases, thus linking it to the broader context of longevity research.

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