Functionally enriched epigenetic clocks reveal tissue-specific discordant aging patterns in individuals with cancer.

Chiara M S Herzog, Elisa Redl, James Barrett, Sepideh Aminzadeh-Gohari, Daniela D Weber, Julia Tevini, Roland Lang, Barbara Kofler, Martin Widschwendter

European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria. · pubmed

Paper

Abstract

Aging is a key risk factor for many diseases, including cancer, and a better understanding of its underlying molecular mechanisms may help to prevent, delay, or treat age-related pathologies. Epigenetic alterations such as DNA methylation (DNAme) changes are a hallmark of aging and form the basis of so-called epigenetic clocks, yet their functional relevance and directionality in different organs during disease development is often unclear.

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Research summary

The paper claims that functionally enriched epigenetic clocks can reveal tissue-specific discordant aging patterns in individuals with cancer. This research is relevant as it explores the molecular mechanisms of aging and their implications in disease, potentially contributing to understanding and addressing age-related pathologies.

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