Melatonin Ameliorates Senescence of Mouse Auditory Cell Line HEI-OC1 Cells by Suppressing NLRP3 Inflammasome-Mediated Pyroptosis.

Yongqing Ding, Yachao Liu, Dong Li, Ruili Hu, Zedong Tian, Lihang Yang, Yanping Li, Yantao Lin, Yan Qu

Department of Otolaryngology, Qiaoxi District, The Third Hospital of Hebei Medical University, No. 13, Ziqiang Road, Shijiazhuang City, Hebei Province, China.Department of Otolaryngology, Qiaoxi District, The Third Hospital of Hebei Medical University, No. 13, Ziqiang Road, Shijiazhuang City, Hebei Province, China. · pubmed

Paper

Abstract

The aim of this study was to determine whether oxidative stress-induced premature senescence in mouse auditory cell line HEI-OC1 cells in vitro is associated with NLRP3 inflammasome activation and pyroptosis, and whether melatonin has a protective effect. HEI-OC1 cells were exposed to different concentrations of hydrogen peroxide (H

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Research summary

Melatonin protects against oxidative stress-induced senescence in HEI-OC1 cells by inhibiting NLRP3 inflammasome-mediated pyroptosis. This study addresses mechanisms of cellular senescence, which are directly related to aging processes.

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