The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice.
Abstract
Androgen receptors (AR) are promising therapeutic targets for mechanisms of aging, including chronic inflammation, lean mass loss, and worsening bone health. We investigated the impact of RAD140, a selective AR modulator that activates ARs, on frailty and underlying mechanisms in older C57BL/6 mice.
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Research summary
The paper investigates the effects of RAD140 on frailty in older mice, suggesting potential mechanisms for addressing age-related decline. The focus on androgen receptors as therapeutic targets for aging-related issues like frailty and lean mass loss indicates a direct relevance to longevity research.
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