Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

Fatemeh Mansouri, Giulia Feliziani, Laura Bordoni, Rosita Gabbianelli

School of Advanced Studies, University of Camerino, Camerino, Italy; Unit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, Camerino, Italy. · pubmed

Paper

Abstract

Resveratrol, a natural polyphenol compound, possesses anti-aging, antitumor, and vascular protective properties. These attributes are believed to stem from its influence on Sirtuin 1 (Sirt1), a member of the human Sirtuin family and a nicotinamide adenine dinucleotide-dependent histone deacetylase.

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Research summary

Resveratrol supplementation positively influences human Sirtuin 1 levels. The paper is relevant as it investigates a compound that may target mechanisms of aging through the modulation of Sirt1, which is associated with longevity and age-related processes.

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