Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli.

Inés Marmisolle, Eliana Chacón, Santiago Mansilla, Santiago Ruiz, Mariana Bresque, Jennyfer Martínez, Ricardo Iván Martínez-Zamudio, Utz Herbig, Jie Liu, Toren Finkel, Carlos Escande, Laura Castro, Celia Quijano

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Uruguay.Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Uruguay. · pubmed

Paper

Abstract

Cellular senescence is characterized by proliferation arrest and a senescence-associated secretory phenotype (SASP), that plays a role in aging and the progression of various age-related diseases. Although various metabolic alterations have been reported, no consensus exists regarding mitochondrial bioenergetics. Here we compared mitochondrial metabolism of human fibroblasts after inducing senescence with different stimuli: the oxidant hydrogen peroxide (H

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Research summary

The paper claims to characterize mitochondrial metabolism in senescent human fibroblasts induced by various stimuli. The focus on mitochondrial bioenergetics in the context of cellular senescence is pertinent to understanding mechanisms of aging and potential interventions.

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