Qualitative and quantitative lipidomic profiling of cardiolipin, oxidized cardiolipin, and monolysocardiolipin from human skeletal muscle by UPLC-Orbitrap-MS

Zhi-Xin Yuan, Josephine M Egan, Arsun Bektas, Qu Tian, Alexey Lyashkov, Luigi Ferrucci, Christopher E Ramsden, Ruin Moaddel

Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address: [email protected] of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Electronic address: [email protected]. · pubmed

Paper

Abstract

Cardiolipins (CL) are a mitochondria-specific family of phospholipids that play central roles in mitochondrial function. Imbalance in CL metabolism, especially excessive CL oxidation, leads to mitochondrial dysfunction, apoptosis, and inflammation, contributing to age-related diseases. As of yet no comprehensive methods have been developed to assess CL, oxidized CL (oxCL), and monolyso-CL (MLCL) species.

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Research summary

The paper presents a comprehensive method for profiling cardiolipin and its oxidized forms in human skeletal muscle. The research is relevant as it addresses mitochondrial dysfunction and its role in age-related diseases, potentially contributing to understanding the root causes of aging.

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