Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.
Abstract
Metabolic dysregulation represents one of the major driving forces in aging. Although multiple genetic and pharmacological manipulations are known to extend longevity in model organisms, aging is a complex trait, and targeting one's own genes may be insufficient to prevent age-dependent deterioration. An alternative strategy could be to use enzymes from other species to reverse age-associated metabolic changes. In this review, we discuss a set of enzymes from lower organisms that have been shown to affect various metabolic parameters linked to age-related processes. These enzymes include modulators of steady-state levels of amino acids (METase, ASNase, and ADI), NADPH/NADP
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Research summary
The paper discusses the potential of using enzymes from lower organisms to reverse age-associated metabolic changes. This research is relevant as it explores innovative strategies to address the root causes of aging rather than merely treating symptoms.
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