Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction are Related to Worsening Healthy Aging Index and Mortality.

Shanshan Yao, Megan M Marron, Qu Tian, Eleanor L Watts, Clary B Clish, Ravi V Shah, Venkatesh L Murthy, Anne B Newman

University of Pittsburgh, Pittsburgh, PA, US.University of Pittsburgh, Pittsburgh, PA, US. · pubmed

Abstract

Metabolic-inflammatory states are central to multiorgan mechanisms of aging, but precise functional biomarkers of physiological aging remain less clear.

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Research summary

The paper claims that specific metabolomic pathways related to inflammation and mitochondrial dysfunction are linked to the Healthy Aging Index and mortality. This research is relevant as it explores underlying metabolic and inflammatory mechanisms that could contribute to aging and longevity, rather than merely addressing symptoms of age-related diseases.

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