Protective effects of carotenoids against blue light induced-cellular damage in human retinal pigment epithelium.
Abstract
The retinal pigmented epithelium (RPE) is constantly exposed to visible light, including blue light (BL) that creates reactive oxygen species (ROS), which are harmful to DNA and induce cellular senescence. Carotenoids are recognized for their antioxidant properties, but their protective effect on DNA repair and cellular senescence under BL induced oxidative stress has not been evaluated. After BL irradiation, the positive senescence-associated-β-galactosidase (SA-β-gal) staining, and gene expression of
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Research summary
The paper claims that carotenoids can protect human retinal pigment epithelium from blue light-induced cellular damage and senescence. This research is relevant as it explores the protective effects of antioxidants against oxidative stress, which is a contributing factor to aging and age-related cellular damage.
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