Alcohol and aging: Next-generation epigenetic clocks predict biological age acceleration in individuals with alcohol use disorder.

Tyler A Perlstein, Jeesun Jung, Alexandra C Wagner, Joshua Reitz, Josephin Wagner, Daniel B Rosoff, Falk W Lohoff

Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA.Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA. · pubmed

Paper

Abstract

Chronic heavy alcohol use is a major risk factor for premature aging and age-related diseases. DNA methylation (DNAm)-based epigenetic clocks are novel tools for predicting biological age. However, the newest configurations, causality-enriched epigenetic clocks, have not been assessed in the context of alcohol consumption and alcohol use disorder (AUD).

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Research summary

The paper claims that next-generation epigenetic clocks can predict biological age acceleration in individuals with alcohol use disorder. This research is relevant as it explores the relationship between alcohol consumption and biological aging, potentially addressing root causes of aging and age-related diseases.

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