Sendotypes predict worsening renal function in chronic kidney disease patients.

Thomas McLarnon, Steven Watterson, Sean McCallion, Eamonn Cooper, Andrew R English, Ying Kuan, David S Gibson, Elaine K Murray, Frank McCarroll, Shu-Dong Zhang, Anthony J Bjourson, Taranjit Singh Rai

School of Medicine, Personalised Medicine Centre, Ulster University, Londonderry, UK.School of Medicine, Personalised Medicine Centre, Ulster University, Londonderry, UK. · pubmed

Paper

Abstract

Senescence associated secretory phenotype (SASP) contributes to age-related pathology, however the role of SASP in Chronic Kidney Disease (CKD) is unclear. Here, we employ a variety of omic techniques to show that senescence signatures can separate CKD patients into distinct senescence endotypes (Sendotype).

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Research summary

The paper claims that distinct senescence endotypes (Sendotype) can predict worsening renal function in chronic kidney disease patients. This research is relevant as it explores the role of senescence in chronic kidney disease, which is an age-related condition, and aims to identify underlying mechanisms that could inform future interventions targeting aging processes.

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